Downloadable Resources

The following resources are provided to inform and support healthcare professionals in caring for patients with HER2 protein overexpressing breast cancer.

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Click here to launch the Herceptin Slide Resource Library. As a PC user, you will have access to view and download PowerPoint slide kits.

If you are a Mac user, please click here to download the PDF version.

For Physicians


Materials
BCIRG 006 Clinical Overview Download (PDF / 200KB)
Herceptin Clinical Information Brochure Download (PDF / 983KB)
BCIRG 006 Slide Kit Download (PDF / 5.15MB)
BCIRG 006 Admin & Dosing Brochure Download (PDF / 415KB)
Herceptin Adjuvant Dosing Guide Download (PDF / 57.2KB)

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HER2 Testing
BCIRG 006 Oncologist ASCO/CAP Guidelines Brochure Download (PDF / 390KB)
BCIRG 006 Surgeon ASCO/CAP Guidelines Brochure Download (PDF / 168KB)
BCIRG 006 Pathologist ASCO/CAP Guidelines Brochure Download (PDF / 168KB)

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General Resources


Reimbursement Information
Reimbursement Information View Information

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For Nurses


Materials
Nurse Checklist Download (PDF / 148KB)
Biology and Treatment of Breast Cancer Download (PDF / 1.03MB)

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HER navigator Program


Phase 1 Materials
NN Playbook 1 Download (PDF / 1.17MB)
NN Letter to Administrators Download (PDF / 110KB)
NN Letter to Patients Download (PDF / 153KB)
Phase 2 Materials
NN Playbook 2 Download (PDF / 2.24MB)
NN Playbook 2 Pocket Card Download (PDF / 194KB)
Answer to HER Questions 1 Download (PDF / 312KB)
Understanding Your Pathology Report (Nurse Version) Download (PDF / 1.30MB)
Understanding Your Pathology Report (Patient Version) Download (PDF / 237KB)
ABC/MBC Flashcard Download (PDF / 300KB)
Unbranded Breast Cancer Fact Sheet Download (PDF / 114KB)

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Patient Materials


The following resources can be offered to your patients to help them better understand HER2 protein overexpressing breast cancer and their treatment options, answer the many questions they may have, and provide additional support in this difficult time in their lives.

Adjuvant Breast Cancer
HER hope - Understanding HER2+ Breast Cancer Download (PDF / 920KB)
HER hope - Understanding HER2+ Breast Cancer (Spanish) Download (PDF / 2.6MB)
General Breast Cancer Resources
Booklets
Your Guide to the Breast Cancer Pathology Report Download (PDF / 576KB)
Overcoming Your Fears of Breast Cancer Treatment Download (PDF / 472 KB)
Your Guide to Breast Cancer Treatment Download (PDF / 576KB)
Caregiver Support Brochure Download (PDF / 408KB)
Fact Sheets
HER2 Disease in Breast Cancer Fact Sheet View Fact Sheets

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  • Adjuvant indications
  • Herceptin is indicated for adjuvant treatment of HER2-overexpressing node-positive or node-negative (ER/PR-negative or with one high-risk feature)† breast cancer:
  • As part of a treatment regimen containing doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel
  • With docetaxel and carboplatin
  • As a single agent following multi-modality anthracycline-based therapy

† High-risk is defined as ER/PR positive with one of the following features: tumor size >2 cm, age <35 years, or tumor grade 2 or 3.

  • Metastatic indications
  • Herceptin is indicated:
  • In combination with paclitaxel for first-line treatment of HER2-overexpressing metastatic breast cancer
  • As a single agent for treatment of HER2-overexpressing breast cancer in patients who have received one or more chemotherapy regimens for metastatic disease

Boxed WARNINGS and Additional Important Safety Information

  • Cardiotoxicity
  • Herceptin administration can result in sub-clinical and clinical cardiac failure manifesting as congestive heart failure (CHF) and decreased left ventricular ejection fraction (LVEF).
    • The incidence and severity of left ventricular cardiac dysfunction was highest in patients who received Herceptin concurrently with anthracycline-containing chemotherapy regimens.
    • Discontinue Herceptin treatment in patients receiving adjuvant therapy for breast cancer and strongly consider discontinuation of Herceptin in patients with metastatic breast cancer who develop a clinically significant decrease in left ventricular function.
  • Herceptin can cause left ventricular cardiac dysfunction, arrhythmias, hypertension, disabling cardiac failure, cardiomyopathy, and cardiac death.
    • In one adjuvant clinical trial, cardiac ischemia or infarction occurred in the Herceptin-containing regimens.
    • Herceptin can also cause asymptomatic decline in LVEF.
  • Cardiac Monitoring
  • Candidates for treatment with Herceptin should undergo a thorough baseline cardiac assessment, including history, physical examination, and an assessment of LVEF by echocardiogram or MUGA scan.
    • Patients should undergo frequent monitoring for decreased left ventricular function during and after Herceptin treatment.
    • More frequent monitoring should be employed if Herceptin is withheld in patients who develop significant left ventricular cardiac dysfunction.
  • Infusion reactions and Pulmonary Toxicity
  • Serious infusion reactions and pulmonary toxicity have occurred; fatal infusion reactions have been reported.
    • In most cases, symptoms occurred during or within 24 hours of administration of Herceptin. Herceptin infusion should be interrupted for patients experiencing dyspnea or clinically significant hypotension.
    • Patients should be monitored until signs and symptoms completely resolve.
    • Discontinue Herceptin for infusion reactions manifesting as anaphylaxis, angioedema, interstitial pneumonitis, or acute respiratory distress
  • Infusion reactions consist of a symptom complex characterized by fever and chills, and on occasion include nausea, vomiting, pain (in some cases at tumor sites), headache, dizziness, dyspnea, hypotension, rash, and asthenia.
    • In postmarketing reports, serious and fatal infusion reactions have been reported. Discontinue Herceptin in all patients with severe or life-threatening infusion reactions.
  • Herceptin use can result in serious and fatal pulmonary toxicity, which includes dyspnea, interstitial pneumonitis, pulmonary infiltrates, pleural effusions, non-cardiogenic pulmonary edema, pulmonary insufficiency and hypoxia, acute respiratory distress syndrome, and pulmonary fibrosis.
    • Such events can occur as sequelae of infusion reactions.
    • Patients with symptomatic intrinsic lung disease or with extensive tumor involvement of the lungs, resulting in dyspnea at rest, appear to have more severe toxicity.
  • Neutropenia
  • Exacerbation of chemotherapy-induced neutropenia has also occurred
    • In controlled clinical trials, severe neutropenia and febrile neutropenia occurred more frequently in metastatic breast cancer patients receiving Herceptin with myelosuppressive chemotherapy compared to chemotherapy alone.
    • The incidence of septic death was not significantly increased.
  • Pregnancy Category D
  • Herceptin can cause fetal harm when administered to a pregnant woman.
  • Post-marketing reports suggest that Herceptin use during pregnancy increases the risk of oligohydramnios during the second and third trimester.
  • Most Common Adverse Events
  • The most common adverse reactions associated with Herceptin use were fever, nausea, vomiting, infusion reactions, diarrhea, infections, increased cough, headache, fatigue, dyspnea, rash, neutropenia, anemia, and myalgia.

Please see the Herceptin full Prescribing Information including Boxed WARNINGS and additional important safety information.



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